Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma
Objectives. The aim of this study was to assess the psychometric properties of the Greek EORTC QLQ-C30 and QLQ-MY20 instruments. Method. A sample of myeloma patients (N=89) from two tertiary hospitals were surveyed with the QLQ-C30, QLQ-MY20 and various demographic and disease related questions. The...
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/842867 |
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| author | Nick Kontodimopoulos Alexandros Samartzis Angelos A. Papadopoulos Dimitris Niakas |
| author_facet | Nick Kontodimopoulos Alexandros Samartzis Angelos A. Papadopoulos Dimitris Niakas |
| author_sort | Nick Kontodimopoulos |
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| description | Objectives. The aim of this study was to assess the psychometric properties of the Greek EORTC QLQ-C30 and QLQ-MY20 instruments. Method. A sample of myeloma patients (N=89) from two tertiary hospitals were surveyed with the QLQ-C30, QLQ-MY20 and various demographic and disease related questions. The previously validated Greek SF-36 instrument was used as a “gold standard” for health-related quality of life (HRQoL) comparisons. Hypothesized scale structure, internal consistency reliability (Cronbach's alpha) and various forms of construct validity (convergent, discriminative, concurrent and known-groups) were assessed. Results. Multitrait scaling confirmed scale structure of the QLQ-C30 and QLQ-MY20, with good item convergence (96% and 72%) and discrimination (78% and 58%) rates. Cronbach's α was >0.70 for all but one scale (cognitive functioning). Spearman's correlations between similar QLQ-C30 and SF-36 scales ranged between 0.35–0.80 (P<0.001). Expected interscale correlations and known-groups comparisons supported construct validity. QLQ-MY20 scales showed comparatively lower correlations with QLQ-C30 functional scales, and higher correlations with conceptually related symptom scales. Conclusions. The observed psychometric properties of the two instruments imply suitability for assessing myeloma HRQoL in Greece. Future studies should focus on generalizability of the results, as well as on specific issues such as longitudinal validity and responsiveness. |
| format | Article |
| id | doaj-art-6a48d01124aa4d7dab9bd4ee59de91d4 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-6a48d01124aa4d7dab9bd4ee59de91d42025-02-03T01:31:34ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/842867842867Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple MyelomaNick Kontodimopoulos0Alexandros Samartzis1Angelos A. Papadopoulos2Dimitris Niakas3School of Social Sciences, Hellenic Open University, Bouboulinas 57-59, 26222 Patras, GreeceSchool of Social Sciences, Hellenic Open University, Bouboulinas 57-59, 26222 Patras, GreeceSchool of Social Sciences, Hellenic Open University, Bouboulinas 57-59, 26222 Patras, GreeceSchool of Social Sciences, Hellenic Open University, Bouboulinas 57-59, 26222 Patras, GreeceObjectives. The aim of this study was to assess the psychometric properties of the Greek EORTC QLQ-C30 and QLQ-MY20 instruments. Method. A sample of myeloma patients (N=89) from two tertiary hospitals were surveyed with the QLQ-C30, QLQ-MY20 and various demographic and disease related questions. The previously validated Greek SF-36 instrument was used as a “gold standard” for health-related quality of life (HRQoL) comparisons. Hypothesized scale structure, internal consistency reliability (Cronbach's alpha) and various forms of construct validity (convergent, discriminative, concurrent and known-groups) were assessed. Results. Multitrait scaling confirmed scale structure of the QLQ-C30 and QLQ-MY20, with good item convergence (96% and 72%) and discrimination (78% and 58%) rates. Cronbach's α was >0.70 for all but one scale (cognitive functioning). Spearman's correlations between similar QLQ-C30 and SF-36 scales ranged between 0.35–0.80 (P<0.001). Expected interscale correlations and known-groups comparisons supported construct validity. QLQ-MY20 scales showed comparatively lower correlations with QLQ-C30 functional scales, and higher correlations with conceptually related symptom scales. Conclusions. The observed psychometric properties of the two instruments imply suitability for assessing myeloma HRQoL in Greece. Future studies should focus on generalizability of the results, as well as on specific issues such as longitudinal validity and responsiveness.http://dx.doi.org/10.1100/2012/842867 |
| spellingShingle | Nick Kontodimopoulos Alexandros Samartzis Angelos A. Papadopoulos Dimitris Niakas Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma The Scientific World Journal |
| title | Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma |
| title_full | Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma |
| title_fullStr | Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma |
| title_full_unstemmed | Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma |
| title_short | Reliability and Validity of the Greek QLQ-C30 and QLQ-MY20 for Measuring Quality of Life in Patients with Multiple Myeloma |
| title_sort | reliability and validity of the greek qlq c30 and qlq my20 for measuring quality of life in patients with multiple myeloma |
| url | http://dx.doi.org/10.1100/2012/842867 |
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