Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy
Transplant recipients who are seronegative for Toxoplasma and receive an organ from a seropositive donor are at high risk for donor-derived toxoplasmosis in the absence of prophylaxis. While the risk in cardiac transplant recipients is well known, this infection is often underrecognized in noncardia...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2024/8839805 |
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| author | Zoe Raglow Emily Herriman Gabriel Abrams Marc Najjar Christopher J. Sonnenday Kevin S. Gregg |
| author_facet | Zoe Raglow Emily Herriman Gabriel Abrams Marc Najjar Christopher J. Sonnenday Kevin S. Gregg |
| author_sort | Zoe Raglow |
| collection | DOAJ |
| description | Transplant recipients who are seronegative for Toxoplasma and receive an organ from a seropositive donor are at high risk for donor-derived toxoplasmosis in the absence of prophylaxis. While the risk in cardiac transplant recipients is well known, this infection is often underrecognized in noncardiac transplant recipients. Toxoplasmosis in transplant patients is associated with high mortality, and diagnosis is challenging as the presentation is nonspecific. Recommendations for prophylaxis in cardiac transplant recipients are well-defined, but the optimal prophylactic strategy in noncardiac transplant recipients, especially those with sulfa allergies, is unknown. We report a case of donor-derived disseminated toxoplasmosis in a liver transplant recipient who did not receive prophylaxis due to documented sulfa allergy. The patient subsequently underwent a challenge with trimethoprim/sulfamethoxazole and was successfully treated with this therapy. This case underscores the variable clinical presentation of donor-derived toxoplasmosis as well as the critical importance of accurate allergy evaluation pretransplant. |
| format | Article |
| id | doaj-art-6a25733f60da4b428ccf4b475ee868c7 |
| institution | Kabale University |
| issn | 2090-6951 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-6a25733f60da4b428ccf4b475ee868c72025-02-03T06:02:22ZengWileyCase Reports in Transplantation2090-69512024-01-01202410.1155/2024/8839805Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa AllergyZoe Raglow0Emily Herriman1Gabriel Abrams2Marc Najjar3Christopher J. Sonnenday4Kevin S. Gregg5Department of Internal MedicineDepartment of SurgerySchool of MedicineDepartment of SurgeryDepartment of SurgeryDepartment of Internal MedicineTransplant recipients who are seronegative for Toxoplasma and receive an organ from a seropositive donor are at high risk for donor-derived toxoplasmosis in the absence of prophylaxis. While the risk in cardiac transplant recipients is well known, this infection is often underrecognized in noncardiac transplant recipients. Toxoplasmosis in transplant patients is associated with high mortality, and diagnosis is challenging as the presentation is nonspecific. Recommendations for prophylaxis in cardiac transplant recipients are well-defined, but the optimal prophylactic strategy in noncardiac transplant recipients, especially those with sulfa allergies, is unknown. We report a case of donor-derived disseminated toxoplasmosis in a liver transplant recipient who did not receive prophylaxis due to documented sulfa allergy. The patient subsequently underwent a challenge with trimethoprim/sulfamethoxazole and was successfully treated with this therapy. This case underscores the variable clinical presentation of donor-derived toxoplasmosis as well as the critical importance of accurate allergy evaluation pretransplant.http://dx.doi.org/10.1155/2024/8839805 |
| spellingShingle | Zoe Raglow Emily Herriman Gabriel Abrams Marc Najjar Christopher J. Sonnenday Kevin S. Gregg Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy Case Reports in Transplantation |
| title | Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy |
| title_full | Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy |
| title_fullStr | Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy |
| title_full_unstemmed | Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy |
| title_short | Donor-Derived Disseminated Toxoplasmosis in a Liver Transplant Recipient With Documented Sulfa Allergy |
| title_sort | donor derived disseminated toxoplasmosis in a liver transplant recipient with documented sulfa allergy |
| url | http://dx.doi.org/10.1155/2024/8839805 |
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