Engineered brain‐targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma

Engineered brain‐targeting exosome for reprogramming immunosuppressive microenvironment of glioblastoma

Abstract The immunosuppressive microenvironment of glioblastoma multiforme (GBM) severely impacts the response to various treatments, including systemic chemotherapy. Targeted reprogramming of immunosuppressive GBM microenvironment using RNA interference (RNAi) is largely restricted by poor brain de...

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Main Authors: Jun Yang, Yong Li, Shaoping Jiang, Yuxin Tian, Mengjie Zhang, Shuai Guo, Pengfei Wu, Jianan Li, Lin Xu, Wenpei Li, Yushu Wang, Huile Gao, Yuanyu Huang, Yuhua Weng, Shaobo Ruan
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Exploration
Subjects:
chemo‐resistance
engineered exosomes
glioblastoma
immunosuppressive microenvironment
RNA interference
Online Access:https://doi.org/10.1002/EXP.20240039
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