The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes
IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17,...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/205284 |
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| _version_ | 1832562535000178688 |
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| author | Monika Ryba-Stanisławowska Maria Skrzypkowska Jolanta Myśliwska Małgorzata Myśliwiec |
| author_facet | Monika Ryba-Stanisławowska Maria Skrzypkowska Jolanta Myśliwska Małgorzata Myśliwiec |
| author_sort | Monika Ryba-Stanisławowska |
| collection | DOAJ |
| description | IL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level. |
| format | Article |
| id | doaj-art-69d6f1d8434b4bedafb8aff83b6c4937 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-69d6f1d8434b4bedafb8aff83b6c49372025-02-03T01:22:28ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/205284205284The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 DiabetesMonika Ryba-Stanisławowska0Maria Skrzypkowska1Jolanta Myśliwska2Małgorzata Myśliwiec3Department of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandDepartment of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandDepartment of Immunology, Medical University of Gdańsk, Dębinki 1, 80-210 Gdańsk, PolandClinic of Pediatrics, Department of Diabetology and Endocrinology, Medical University of Gdańsk, 80-210 Gdańsk, PolandIL-6 is a pleiotropic cytokine involved in the regulation of the immune response, inflammation, and hematopoeisis. Its elevated levels are found in a range of autoimmune and chronic inflammatory diseases. IL-6 is also involved in regulation of the balance between two T cell subsets: Tregs and Th17, which have contradictory functions in the control of inflammation. The present study provides a quantitative analysis regarding the Th17/Treg cell balance in peripheral blood of children with type 1 diabetes and its association with serum IL-6 level.http://dx.doi.org/10.1155/2013/205284 |
| spellingShingle | Monika Ryba-Stanisławowska Maria Skrzypkowska Jolanta Myśliwska Małgorzata Myśliwiec The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes Mediators of Inflammation |
| title | The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes |
| title_full | The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes |
| title_fullStr | The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes |
| title_full_unstemmed | The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes |
| title_short | The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes |
| title_sort | serum il 6 profile and treg th17 peripheral cell populations in patients with type 1 diabetes |
| url | http://dx.doi.org/10.1155/2013/205284 |
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