Evaluation of thrombomodulin (THBD) plasma levels in sickle cell disease and correlation with disease severity

Abstract Background Endothelial dysfunction is a hallmark of sickle vasculopathy. Thrombomodulin (THBD) is a transmembrane protein expressed on vascular endothelial cells suppressing blood coagulation and exerting anti-inflammatory effects. It is a known biomarker of endothelial injury and its eleva...

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Bibliographic Details
Main Authors: Yasmeen M.M. Selim, Amina Abdelsalam, Eman A. Youssef, Abdelkarem Bahy, Dalia El-Sayed
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Egyptian Pediatric Association Gazette
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Online Access:https://doi.org/10.1186/s43054-025-00373-8
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