The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT

The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT

ABSTRACT The eukaryotic CCR4−NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen. We show that a translocated bacterial effector protein, PieF (Lpg1972...

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Bibliographic Details
Main Authors: Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSphere
Subjects:
Legionella pneumophila
host-pathogen interaction
deadenylation
CCR4-NOT
mRNA stability
PieF
Online Access:https://journals.asm.org/doi/10.1128/msphere.00891-24
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https://journals.asm.org/doi/10.1128/msphere.00891-24

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