Astrocytic connexin43 in the medial prefrontal cortex regulates depressive- and anxiety-like behaviors via ATP release

Astrocytic connexin43 in the medial prefrontal cortex regulates depressive- and anxiety-like behaviors via ATP release

Major depressive disorder (MDD) affects 17 % of the global population and is highly comorbid with anxiety disorders. Emerging evidence indicates that dysregulation of astrocytic ATP contributes to the pathophysiology of depression. However, the molecular substrates underlying the stress-induced redu...

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Main Authors: Meng-Ling Wang, Yun-Long Song, Ding-Yu Wu, Hao Li, Zi-Ming Li, Xing-Xing Xiong, Neng-Yuan Hu, Jian Hu, Jing-Ting Li, Yue-Xin Wang, Xiao-Wen Li, Jian-Ming Yang, Yi-Hua Chen, Tian-Ming Gao
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Pharmacological Research
Subjects:
Depression
Anxiety
Astrocyte
Connexin 43
ATP
mPFC
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002233
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