Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromosomic animal carrying human chromosome 21. We incor...

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Main Authors: Nick M Powell, Marc Modat, M Jorge Cardoso, Da Ma, Holly E Holmes, Yichao Yu, James O'Callaghan, Jon O Cleary, Ben Sinclair, Frances K Wiseman, Victor L J Tybulewicz, Elizabeth M C Fisher, Mark F Lythgoe, Sébastien Ourselin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0162974&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0162974&type=printable

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