Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice
Most patients with psoriasis present with localized mild-to-moderate disease. In this case, the application of topical treatments in the first-line setting is recommended in most cases.Among different topical options, the fixed-dose combination of betamethasone dipropionate (BD) and vitamin D analog...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-07-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2021.1998310 |
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| author | Gabriella Fabbrocini Clara De Simone Paolo Dapavo Perigiorgio Malagoli Alessandro Martella Piergiacomo Calzavara-Pinton |
| author_facet | Gabriella Fabbrocini Clara De Simone Paolo Dapavo Perigiorgio Malagoli Alessandro Martella Piergiacomo Calzavara-Pinton |
| author_sort | Gabriella Fabbrocini |
| collection | DOAJ |
| description | Most patients with psoriasis present with localized mild-to-moderate disease. In this case, the application of topical treatments in the first-line setting is recommended in most cases.Among different topical options, the fixed-dose combination of betamethasone dipropionate (BD) and vitamin D analogue (Cal) aerosol foam (Enstilar®, Leo Pharma) is approved as first-line topical therapy for the treatment of psoriasis in USA and the EU, due to its high efficacy and its favorable administration scheme.The PSO-LONG was the first trial to report on the long-term efficacy and safety of the Cal/DB foam treatment for the proactive management of psoriasis and now, the indications of Cal/BD foam included its use in the psoriasis maintenance treatment. However, the precise role of this treatment and the potential therapeutic schemes in the long-term management of psoriasis need further clarification.This Position Paper, authored by a group of Italian Expert Dermatologists, critically discusses the long-term management of psoriasis with Cal/BD foam in clinical practice. In particular, the biological rationale in the proactive treatment with Cal/BD foam and current evidence regarding this therapeutic approach are presented, along with its application also in patients with moderate-to-severe disease, difficult-to-treat lesions, or within combination regimens. In addition, strategies to improve adherence to long-term treatment of psoriasis are discussed, |
| format | Article |
| id | doaj-art-6908086882564bafbdfeacb70be30cfe |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-6908086882564bafbdfeacb70be30cfe2025-02-05T19:02:55ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-07-013352425243210.1080/09546634.2021.1998310Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practiceGabriella Fabbrocini0Clara De Simone1Paolo Dapavo2Perigiorgio Malagoli3Alessandro Martella4Piergiacomo Calzavara-Pinton5Department of Clinical Medicine and Surgery, Section of Dermatology, Federico II University of Naples, Naples, ItalyDepartment of Dermatology, Catholic University of the Sacred Heart, Policlinico “A. Gemelli", IRCCS, Rome, ItalyASO City of Health and Science, University Dermatological Clinic, Torino, ItalyHead Psocare Unit, IRCCS Policlinico San Donato, Milano, ItalyMyskin Dermatology Practice, Tiggiano, Lecce, ItalyDermatology Department, University of Brescia, ASST Spedali Civili, Brescia, ItalyMost patients with psoriasis present with localized mild-to-moderate disease. In this case, the application of topical treatments in the first-line setting is recommended in most cases.Among different topical options, the fixed-dose combination of betamethasone dipropionate (BD) and vitamin D analogue (Cal) aerosol foam (Enstilar®, Leo Pharma) is approved as first-line topical therapy for the treatment of psoriasis in USA and the EU, due to its high efficacy and its favorable administration scheme.The PSO-LONG was the first trial to report on the long-term efficacy and safety of the Cal/DB foam treatment for the proactive management of psoriasis and now, the indications of Cal/BD foam included its use in the psoriasis maintenance treatment. However, the precise role of this treatment and the potential therapeutic schemes in the long-term management of psoriasis need further clarification.This Position Paper, authored by a group of Italian Expert Dermatologists, critically discusses the long-term management of psoriasis with Cal/BD foam in clinical practice. In particular, the biological rationale in the proactive treatment with Cal/BD foam and current evidence regarding this therapeutic approach are presented, along with its application also in patients with moderate-to-severe disease, difficult-to-treat lesions, or within combination regimens. In addition, strategies to improve adherence to long-term treatment of psoriasis are discussed,https://www.tandfonline.com/doi/10.1080/09546634.2021.1998310Psoriasisproactive managementlong-term therapyCal/BDadherence |
| spellingShingle | Gabriella Fabbrocini Clara De Simone Paolo Dapavo Perigiorgio Malagoli Alessandro Martella Piergiacomo Calzavara-Pinton Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice Journal of Dermatological Treatment Psoriasis proactive management long-term therapy Cal/BD adherence |
| title | Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice |
| title_full | Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice |
| title_fullStr | Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice |
| title_full_unstemmed | Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice |
| title_short | Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice |
| title_sort | long term maintenance treatment of psoriasis the role of calcipotriol betamethasone dipropionate aerosol foam in clinical practice |
| topic | Psoriasis proactive management long-term therapy Cal/BD adherence |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2021.1998310 |
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