MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study
We investigated structural brain differences between a group of early-mild PD patients at different phases of the disease and healthy subjects using voxel-based morphometry (VBM). 20 mild PD patients compared to 15 healthy at baseline and after 2 years of follow-up. VBM is a fully automated techniqu...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2015/378032 |
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| author | Valentina Fioravanti Francesca Benuzzi Luca Codeluppi Sara Contardi Francesco Cavallieri Paolo Nichelli Franco Valzania |
| author_facet | Valentina Fioravanti Francesca Benuzzi Luca Codeluppi Sara Contardi Francesco Cavallieri Paolo Nichelli Franco Valzania |
| author_sort | Valentina Fioravanti |
| collection | DOAJ |
| description | We investigated structural brain differences between a group of early-mild PD patients at different phases of the disease and healthy subjects using voxel-based morphometry (VBM). 20 mild PD patients compared to 15 healthy at baseline and after 2 years of follow-up. VBM is a fully automated technique, which allows the identification of regional differences in the gray matter enabling an objective analysis of the whole brain between groups of subjects. With respect to controls, PD patients exhibited decreased GM volumes in right putamen and right parietal cortex. After 2 years of disease, the same patients confirmed GM loss in the putamen and parietal cortex; a significant difference was also observed in the area of pedunculopontine nucleus (PPN) and in the mesencephalic locomotor region (MLR). PD is associated with brain morphological changes in cortical and subcortical structures. The first regions to be affected in PD seem to be the parietal cortex and the putamen. A third structure that undergoes atrophy is the part of the inferior-posterior midbrain, attributable to the PPN and MLR. Our findings provide new insight into the brain involvement in PD and could contribute to a better understanding of the sequence of events occurring in these patients. |
| format | Article |
| id | doaj-art-6863e8ae192e436ba3ef6bc9d57cfbe7 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-6863e8ae192e436ba3ef6bc9d57cfbe72025-02-03T01:09:27ZengWileyParkinson's Disease2090-80832042-00802015-01-01201510.1155/2015/378032378032MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry StudyValentina Fioravanti0Francesca Benuzzi1Luca Codeluppi2Sara Contardi3Francesco Cavallieri4Paolo Nichelli5Franco Valzania6Department of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyDepartment of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyDepartment of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyDepartment of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyDepartment of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyDepartment of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyDepartment of Neuroscience, Nuovo Ospedale Civile S. Agostino-Estense, University of Modena and Reggio Emilia, Viale Giardini 1355, 41126 Modena, ItalyWe investigated structural brain differences between a group of early-mild PD patients at different phases of the disease and healthy subjects using voxel-based morphometry (VBM). 20 mild PD patients compared to 15 healthy at baseline and after 2 years of follow-up. VBM is a fully automated technique, which allows the identification of regional differences in the gray matter enabling an objective analysis of the whole brain between groups of subjects. With respect to controls, PD patients exhibited decreased GM volumes in right putamen and right parietal cortex. After 2 years of disease, the same patients confirmed GM loss in the putamen and parietal cortex; a significant difference was also observed in the area of pedunculopontine nucleus (PPN) and in the mesencephalic locomotor region (MLR). PD is associated with brain morphological changes in cortical and subcortical structures. The first regions to be affected in PD seem to be the parietal cortex and the putamen. A third structure that undergoes atrophy is the part of the inferior-posterior midbrain, attributable to the PPN and MLR. Our findings provide new insight into the brain involvement in PD and could contribute to a better understanding of the sequence of events occurring in these patients.http://dx.doi.org/10.1155/2015/378032 |
| spellingShingle | Valentina Fioravanti Francesca Benuzzi Luca Codeluppi Sara Contardi Francesco Cavallieri Paolo Nichelli Franco Valzania MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study Parkinson's Disease |
| title | MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study |
| title_full | MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study |
| title_fullStr | MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study |
| title_full_unstemmed | MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study |
| title_short | MRI Correlates of Parkinson’s Disease Progression: A Voxel Based Morphometry Study |
| title_sort | mri correlates of parkinson s disease progression a voxel based morphometry study |
| url | http://dx.doi.org/10.1155/2015/378032 |
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