Berbamine as potential STING inhibitor For KRAS-mutant non-small cell lung cancer

Berbamine as potential STING inhibitor For KRAS-mutant non-small cell lung cancer

Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality. Poor prognostic results in LUAD are frequently associated with KRAS mutations and drug resistance. KRAS mutations can induce STING activation by triggering DNA damage response (DDR) activation. This persistently activated STI...

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Bibliographic Details
Main Authors: Haoxin Yan, Jumin Huang, Yuwei Wang, Yizhong Zhang, Wenkang Ren, Zhiran Zhai, Yuping Tang, Huanling Lai, Xingxing Fan, Lihua Liu, Elaine Lai-Han Leung
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Pharmacological Research
Subjects:
NSCLC
STING
MDSCs
Berbamine
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002026
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