Foodborne toxin Aflatoxin B1 induced glomerular podocyte inflammation through proteolysis of RelA, downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway

Foodborne toxin Aflatoxin B1 induced glomerular podocyte inflammation through proteolysis of RelA, downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway

Aflatoxin B1 (AFB1) is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin, particularly causing damages to kidney. Glomerular podocytes are terminally differentiated epithelial cells. AFB1 induces podocyte inflammation, proteinuria and renal dysfunction. Studying the me...

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Bibliographic Details
Main Authors: Jie Zhang, Shuang Yang, Baocai Xu, Zihui Qin, Xinyi Guo, Ben Wei, Qinghua Wu, Kamil Kuca, Tushuai Li, Wenda Wu
Format: Article
Language:English
Published: Tsinghua University Press 2024-07-01
Series:Food Science and Human Wellness
Subjects:
afl atoxin b1
podocyte infl ammation
mirna-9
chemokine (c-x-c motif) receptor 4
rela ubiquitin-dependent degradation
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2022.9250191
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https://www.sciopen.com/article/10.26599/FSHW.2022.9250191

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