AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation
AlphaFold2 predicts protein structures from structural and functional knowledge. Alternatively, ESMFold does the same adopting protein language models. Here, we map available Pfam domains on pairs of models of the human reference proteome computed with both procedures and we compare the mapped regio...
Saved in:
Main Authors: | Matteo Manfredi, Gabriele Vazzana, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2025-01-01
|
Series: | Computational and Structural Biotechnology Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S200103702500008X |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
An outlook on structural biology after AlphaFold: tools, limits and perspectives
by: Serena Rosignoli, et al.
Published: (2025-02-01) -
AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease
by: Lulu Zhang, et al.
Published: (2025-02-01) -
AlphaFold 2, but not AlphaFold 3, predicts confident but unrealistic β-solenoid structures for repeat proteins
by: Olivia S. Pratt, et al.
Published: (2025-01-01) -
Single-cell RNA sequencing and AlphaFold 3 insights into cytokine signaling and its role in uveal melanoma
by: Hongyan Sun, et al.
Published: (2025-01-01) -
Structural engineering of stabilized, expanded epitope nanoparticle vaccines for HPV
by: Michaela Helble, et al.
Published: (2025-01-01)