AlphaFold2 and ESMFold: A large-scale pairwise model comparison of human enzymes upon Pfam functional annotation

AlphaFold2 predicts protein structures from structural and functional knowledge. Alternatively, ESMFold does the same adopting protein language models. Here, we map available Pfam domains on pairs of models of the human reference proteome computed with both procedures and we compare the mapped regio...

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Bibliographic Details
Main Authors: Matteo Manfredi, Gabriele Vazzana, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Computational and Structural Biotechnology Journal
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Online Access:http://www.sciencedirect.com/science/article/pii/S200103702500008X
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