Placebo effects improve sickness symptoms and drug efficacy during systemic inflammation: a randomized controlled trial in human experimental endotoxemia

Placebo effects improve sickness symptoms and drug efficacy during systemic inflammation: a randomized controlled trial in human experimental endotoxemia

Abstract Background Systemic inflammation triggers a wide range of sickness symptoms, including bodily discomfort and affective symptoms, which are relevant to numerous health conditions. While extensive research in the placebo field demonstrates that positive expectations can improve symptoms, it r...

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Bibliographic Details
Main Authors: Justine Schmidt, Johanna Reinold, Hana Rohn, Manfred Schedlowski, Harald Engler, Sigrid Elsenbruch, Sven Benson
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Medicine
Subjects:
Inflammation
Endotoxemia
Lipopolysaccharide
Placebo effect
Expectations
Sickness behaviour
Online Access:https://doi.org/10.1186/s12916-025-04292-8
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https://doi.org/10.1186/s12916-025-04292-8

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