Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis
Oxazolidinone antibiotics—linezolid and tedizolid—are often used to treat multidrug-resistant infections. They are highly bioavailable and ideal for transition to enteral therapy when appropriate. However, multiple associated adverse effects are potentially treatment-limiting. The objective of this...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | Antimicrobial Stewardship & Healthcare Epidemiology |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2732494X2400487X/type/journal_article |
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| author | Adam Greenfield Erin Deja Kimberly Lee Sangeeta Sastry Barry Rittmann |
| author_facet | Adam Greenfield Erin Deja Kimberly Lee Sangeeta Sastry Barry Rittmann |
| author_sort | Adam Greenfield |
| collection | DOAJ |
| description | Oxazolidinone antibiotics—linezolid and tedizolid—are often used to treat multidrug-resistant infections. They are highly bioavailable and ideal for transition to enteral therapy when appropriate. However, multiple associated adverse effects are potentially treatment-limiting. The objective of this review is to discuss relevant adverse effects of linezolid and tedizolid, including serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis, and their commonality in real-world experience in the last decade. Mitigation strategies, including the role of therapeutic drug monitoring, are also discussed. |
| format | Article |
| id | doaj-art-6801f9ee13c94d1880ddebcf257dab1a |
| institution | Kabale University |
| issn | 2732-494X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Antimicrobial Stewardship & Healthcare Epidemiology |
| spelling | doaj-art-6801f9ee13c94d1880ddebcf257dab1a2025-01-27T10:13:08ZengCambridge University PressAntimicrobial Stewardship & Healthcare Epidemiology2732-494X2025-01-01510.1017/ash.2024.487Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosisAdam Greenfield0https://orcid.org/0000-0002-8417-9575Erin Deja1https://orcid.org/0009-0009-1199-6791Kimberly Lee2Sangeeta Sastry3https://orcid.org/0009-0002-1342-8252Barry Rittmann4https://orcid.org/0009-0001-2983-1364Department of Pharmacy, UPMC St. Margaret, Pittsburgh, PA, USADepartment of Pharmacy, Virginia Commonwealth University Health System, Richmond, VA, USADepartment of Pharmacy, Virginia Commonwealth University Health System, Richmond, VA, USADepartment of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Health System, Richmond, VA, USADepartment of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Health System, Richmond, VA, USAOxazolidinone antibiotics—linezolid and tedizolid—are often used to treat multidrug-resistant infections. They are highly bioavailable and ideal for transition to enteral therapy when appropriate. However, multiple associated adverse effects are potentially treatment-limiting. The objective of this review is to discuss relevant adverse effects of linezolid and tedizolid, including serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis, and their commonality in real-world experience in the last decade. Mitigation strategies, including the role of therapeutic drug monitoring, are also discussed.https://www.cambridge.org/core/product/identifier/S2732494X2400487X/type/journal_article |
| spellingShingle | Adam Greenfield Erin Deja Kimberly Lee Sangeeta Sastry Barry Rittmann Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis Antimicrobial Stewardship & Healthcare Epidemiology |
| title | Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis |
| title_full | Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis |
| title_fullStr | Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis |
| title_full_unstemmed | Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis |
| title_short | Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis |
| title_sort | linezolid and tedizolid adverse effects a review on serotonin syndrome myelosuppression neuropathies and lactic acidosis |
| url | https://www.cambridge.org/core/product/identifier/S2732494X2400487X/type/journal_article |
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