An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity.

An OMV Vaccine Derived from a Capsular Group B Meningococcus with Constitutive FetA Expression: Preclinical Evaluation of Immunogenicity and Toxicity.

Following the introduction of effective protein-polysaccharide conjugate vaccines against capsular group C meningococcal disease in Europe, meningococci of capsular group B remain a major cause of death and can result in debilitating sequelae. The outer membrane proteins PorA and FetA have previousl...

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Main Authors: Gunnstein Norheim, Holly Sanders, Jardar W Mellesdal, Idunn Sundfør, Hannah Chan, Carina Brehony, Caroline Vipond, Chris Dold, Rory Care, Muhammad Saleem, Martin C J Maiden, Jeremy P Derrick, Ian Feavers, Andrew J Pollard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0134353
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https://doi.org/10.1371/journal.pone.0134353

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