Syringaldehyde Alleviates Cardiac Hypertrophy Induced by Hyperglycemia in H9c2 Cells Through GLP-1 Receptor Signals

Syringaldehyde Alleviates Cardiac Hypertrophy Induced by Hyperglycemia in H9c2 Cells Through GLP-1 Receptor Signals

<b>Background:</b> Cardiac hypertrophy is a significant complication of diabetes, often triggered by hyperglycemia. Glucagon-like peptide-1 (GLP-1) receptor agonists alleviate cardiac hypertrophy, but their efficacy diminishes under GLP-1 resistance. Syringaldehyde (SA), a natural phenol...

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Bibliographic Details
Main Authors: Yingxiao Li, Chao-Tien Hsu, Ting-Ting Yang, Kai-Chun Cheng
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
AMPK
cardiac hypertrophy
diabetes complications
GLP-1 resistance
O-linked N-acetylglucosamine transferase (OGT)
syringaldehyde
Online Access:https://www.mdpi.com/1424-8247/18/1/110
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