dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening

dFLASH; dual FLuorescent transcription factor activity sensor for histone integrated live-cell reporting and high-content screening

Abstract Live-cell transcription factor (TF) activity reporting is crucial for synthetic biology, drug discovery and functional genomics. Here we present dFLASH (dual FLuorescent transcription factor Activity Sensor for Histone-integrated live-cell reporting), a modular, genome-integrated TF sensor....

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Main Authors: Timothy P. Allen, Alison E. Roennfeldt, Moganalaxmi Reckdharajkumar, Adrienne E. Sullivan, Miaomiao Liu, Ronald J. Quinn, Darryl L. Russell, Daniel J. Peet, Murray L. Whitelaw, David C. Bersten
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58488-w
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https://doi.org/10.1038/s41467-025-58488-w

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