Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion
Given the present lack of clinically useful tests for the accurate diagnosis of ectopic pregnancy (EP), there is a need to select out those immunological factors measured in the maternal serum, as potential biomarkers. Our assumption was that C1q/anti-C1q antibody complexes and serum levels of inter...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/637513 |
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| author | Alexandros Daponte Efthimios Deligeoroglou Spyros Pournaras Christos Hadjichristodoulou Antonios Garas Foteini Anastasiadou Ioannis E. Messinis |
| author_facet | Alexandros Daponte Efthimios Deligeoroglou Spyros Pournaras Christos Hadjichristodoulou Antonios Garas Foteini Anastasiadou Ioannis E. Messinis |
| author_sort | Alexandros Daponte |
| collection | DOAJ |
| description | Given the present lack of clinically useful tests for the accurate diagnosis of ectopic pregnancy (EP), there is a need to select out those immunological factors measured in the maternal serum, as potential biomarkers. Our assumption was that C1q/anti-C1q antibody complexes and serum levels of interleukin-15 (IL-15) may play a role in differentiating abortions (MAs) and EPs and normal pregnancies. We assessed whether their measurement could set the diagnosis in a case control study at 6–8 weeks consisting of 60 women with failed early pregnancy (30 EPs, 30 MAs) and 33 women with intrauterine pregnancies. Normal pregnancies contain anti-C1q antibodies more frequently compared to women with failed pregnancies, the lowest levels being found in EPs, but this lacked statistical significance and anti-C1q could not serve as a marker. However EP pregnancies had elevated IL-15 levels that could statistically significantly differentiate them from MAs and IUPs. Furthermore, when assessing IL-15 for the clinically important differentiation between IUP and EP, we found at a cut-off of 16 pg/mL a negative predictive value of 99 with a sensitivity for diagnosing an EP of 92%. According to these results, serum IL-15 is a promising marker differentiating an MA from an EP. |
| format | Article |
| id | doaj-art-6768e824f6434f16aed6df14b92791dc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-6768e824f6434f16aed6df14b92791dc2025-02-03T05:53:55ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/637513637513Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed AbortionAlexandros Daponte0Efthimios Deligeoroglou1Spyros Pournaras2Christos Hadjichristodoulou3Antonios Garas4Foteini Anastasiadou5Ioannis E. Messinis6Department of Obstetrics and Gynecology, University of Thessaly Medical School, University Hospital Larissa, Biopolis, 41110 Larissa, GreeceDivision of Pediatric, Adolescent Gynecology and Reconstructive Surgery, 2nd Department of Obstetrics and Gynecology, Medical School, University of Athens and Aretaieion Hospital, Vasilisis Sofias 76, 11528 Athens, GreeceDepartment of Clinical Chemistry, University of Thessaly Medical School, University Hospital Larissa, Biopolis, 41110 Larissa, GreeceDepartment of Hygiene and Epidemiology, University of Thessaly Medical School, University Hospital Larissa, 6 Lapithon Street, Biopolis, 41221 Larissa, GreeceDepartment of Obstetrics and Gynecology, University of Thessaly Medical School, University Hospital Larissa, Biopolis, 41110 Larissa, GreeceDepartment of Obstetrics and Gynecology, University of Thessaly Medical School, University Hospital Larissa, Biopolis, 41110 Larissa, GreeceDepartment of Obstetrics and Gynecology, University of Thessaly Medical School, University Hospital Larissa, Biopolis, 41110 Larissa, GreeceGiven the present lack of clinically useful tests for the accurate diagnosis of ectopic pregnancy (EP), there is a need to select out those immunological factors measured in the maternal serum, as potential biomarkers. Our assumption was that C1q/anti-C1q antibody complexes and serum levels of interleukin-15 (IL-15) may play a role in differentiating abortions (MAs) and EPs and normal pregnancies. We assessed whether their measurement could set the diagnosis in a case control study at 6–8 weeks consisting of 60 women with failed early pregnancy (30 EPs, 30 MAs) and 33 women with intrauterine pregnancies. Normal pregnancies contain anti-C1q antibodies more frequently compared to women with failed pregnancies, the lowest levels being found in EPs, but this lacked statistical significance and anti-C1q could not serve as a marker. However EP pregnancies had elevated IL-15 levels that could statistically significantly differentiate them from MAs and IUPs. Furthermore, when assessing IL-15 for the clinically important differentiation between IUP and EP, we found at a cut-off of 16 pg/mL a negative predictive value of 99 with a sensitivity for diagnosing an EP of 92%. According to these results, serum IL-15 is a promising marker differentiating an MA from an EP.http://dx.doi.org/10.1155/2013/637513 |
| spellingShingle | Alexandros Daponte Efthimios Deligeoroglou Spyros Pournaras Christos Hadjichristodoulou Antonios Garas Foteini Anastasiadou Ioannis E. Messinis Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion Clinical and Developmental Immunology |
| title | Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion |
| title_full | Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion |
| title_fullStr | Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion |
| title_full_unstemmed | Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion |
| title_short | Interleukin-15 (IL-15) and Anti-C1q Antibodies as Serum Biomarkers for Ectopic Pregnancy and Missed Abortion |
| title_sort | interleukin 15 il 15 and anti c1q antibodies as serum biomarkers for ectopic pregnancy and missed abortion |
| url | http://dx.doi.org/10.1155/2013/637513 |
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