The effects of voltage dependence and ion-binding reaction rates on a thermodynamically constrained mathematical model of the Na/Ca exchanger

The effects of voltage dependence and ion-binding reaction rates on a thermodynamically constrained mathematical model of the Na/Ca exchanger

Abstract Specialized mathematical models have been proposed to quantitatively assess the ion transporter performance in heart-related physiological experiments. The Na/Ca exchanger imports three Na+ ions into the cell and exports one Ca2+ ion; therefore, it plays a vital role in cardiomyocyte ion ho...

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Bibliographic Details
Main Authors: Shaocong Ou, Zhongyang Xiao, Keika Oyama, Masaaki Furukawa, Yuttamol Muangkram, Yukiko Himeno, Akira Amano
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Na/Ca Exchanger
Voltage Dependence
Thermodynamics
Charge Transfer
Mathematical Model
Online Access:https://doi.org/10.1038/s41598-025-07881-y
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https://doi.org/10.1038/s41598-025-07881-y

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