Genes Involved in the Biosynthesis and Transport of Acinetobactin in
Pathogenic bacteria survive in iron-limited host environments by using several iron acquisition mechanisms. Acinetobacter baumannii, causing serious infections in compromised patients, produces an iron-chelating molecule, called acinetobactin, which is composed of equimolar quantities of 2,3-dihydro...
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BioMed Central
2015-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-13-2.pdf |
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| author | Tarik Hasan Chul Hee Choi Man Hwan Oh |
| author_facet | Tarik Hasan Chul Hee Choi Man Hwan Oh |
| author_sort | Tarik Hasan |
| collection | DOAJ |
| description | Pathogenic bacteria survive in iron-limited host environments by using several iron acquisition mechanisms. Acinetobacter baumannii, causing serious infections in compromised patients, produces an iron-chelating molecule, called acinetobactin, which is composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine, to compete with host cells for iron. Genes that are involved in the production and transport of acinetobactin are clustered within the genome of A. baumannii. A recent study showed that entA, located outside of the acinetobactin gene cluster, plays important roles in the biosynthesis of the acinetobactin precursor DHBA and in bacterial pathogenesis. Therefore, understanding the genes that are associated with the biosynthesis and transport of acinetobactin in the bacterial genome is required. This review is intended to provide a general overview of the genes in the genome of A. baumannii that are required for acinetobactin biosynthesis and transport. |
| format | Article |
| id | doaj-art-671df36e6e2d44bfabb09d92157bce6b |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | BioMed Central |
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| series | Genomics & Informatics |
| spelling | doaj-art-671df36e6e2d44bfabb09d92157bce6b2025-02-02T15:03:47ZengBioMed CentralGenomics & Informatics1598-866X2234-07422015-03-011312610.5808/GI.2015.13.1.2145Genes Involved in the Biosynthesis and Transport of Acinetobactin inTarik Hasan0Chul Hee Choi1Man Hwan Oh2Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea.Department of Microbiology and Research Institute for Medical Sciences, Chungnam National University College of Medicine, Daejeon 301-747, Korea.Department of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 330-714, Korea.Pathogenic bacteria survive in iron-limited host environments by using several iron acquisition mechanisms. Acinetobacter baumannii, causing serious infections in compromised patients, produces an iron-chelating molecule, called acinetobactin, which is composed of equimolar quantities of 2,3-dihydroxybenzoic acid (DHBA), L-threonine, and N-hydroxyhistamine, to compete with host cells for iron. Genes that are involved in the production and transport of acinetobactin are clustered within the genome of A. baumannii. A recent study showed that entA, located outside of the acinetobactin gene cluster, plays important roles in the biosynthesis of the acinetobactin precursor DHBA and in bacterial pathogenesis. Therefore, understanding the genes that are associated with the biosynthesis and transport of acinetobactin in the bacterial genome is required. This review is intended to provide a general overview of the genes in the genome of A. baumannii that are required for acinetobactin biosynthesis and transport.http://genominfo.org/upload/pdf/gni-13-2.pdfacinetobactinironsiderophores |
| spellingShingle | Tarik Hasan Chul Hee Choi Man Hwan Oh Genes Involved in the Biosynthesis and Transport of Acinetobactin in Genomics & Informatics acinetobactin iron siderophores |
| title | Genes Involved in the Biosynthesis and Transport of Acinetobactin in |
| title_full | Genes Involved in the Biosynthesis and Transport of Acinetobactin in |
| title_fullStr | Genes Involved in the Biosynthesis and Transport of Acinetobactin in |
| title_full_unstemmed | Genes Involved in the Biosynthesis and Transport of Acinetobactin in |
| title_short | Genes Involved in the Biosynthesis and Transport of Acinetobactin in |
| title_sort | genes involved in the biosynthesis and transport of acinetobactin in |
| topic | acinetobactin iron siderophores |
| url | http://genominfo.org/upload/pdf/gni-13-2.pdf |
| work_keys_str_mv | AT tarikhasan genesinvolvedinthebiosynthesisandtransportofacinetobactinin AT chulheechoi genesinvolvedinthebiosynthesisandtransportofacinetobactinin AT manhwanoh genesinvolvedinthebiosynthesisandtransportofacinetobactinin |