Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples

Pharmacokinetic and pharmacodynamic analyses of nafamostat in ECMO patients: comparing central vein and ECMO machine samples

ObjectivesTo better understand nafamostat mesylate (NM) dose requirements during extracorporeal membrane oxygenation (ECMO), this study investigated its pharmacokinetic/pharmacodynamic (PK/PD) properties by comparing samples from the systemic circulation of patients and from the ECMO circuit. It spe...

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Main Authors: Dong Hwan Lee, Jae Ha Lee, Ji Hoon Jang, Yong Kyun Kim, Gaeun Kang, So Young Jung, Minyoung Her, Hang Jea Jang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
nafamostat mesylate
extracorporeal membrane oxygenation
pharmacokinetics
pharmacodynamics
nonlinear mixed effect model
turnover model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1541131/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1541131/full

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