The dual antioxidant chitosan oligosaccharides regulate the transdifferentiation of lung effector cells in the management of idiopathic pulmonary fibrosis

The dual antioxidant chitosan oligosaccharides regulate the transdifferentiation of lung effector cells in the management of idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with limited treatment options. This study investigates the therapeutic potential of chitosan oligosaccharides (COS), a natural carbohydrate with antioxidant properties, in comparison to the FDA-approved drug pirfenidone (PFD). B...

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Bibliographic Details
Main Authors: Huan He, Youtao Xu, Xinru Chen, Jiawen Wu, Xianpeng Zhong, Xiyu Li, Jing Qiao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Carbohydrate Polymer Technologies and Applications
Subjects:
Idiopathic pulmonary fibrosis
Chitosan oligosaccharides
Epithelial‒mesenchymal transition;, Fibroblast‒myofibroblast transition
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2666893925001203
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