EEG Correlates of Central Origin of Cancer-Related Fatigue
The neurophysiological mechanism of cancer-related fatigue (CRF) remains poorly understood. EEG was examined during a sustained submaximal contraction (SC) task to further understand our prior research findings of greater central contribution to early fatigue during SC in CRF. Advanced cancer patien...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8812984 |
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| author | Didier Allexandre Dilara Seyidova-Khoshknabi Mellar P. Davis Vinoth K. Ranganathan Vlodek Siemionow Declan Walsh Guang H. Yue |
| author_facet | Didier Allexandre Dilara Seyidova-Khoshknabi Mellar P. Davis Vinoth K. Ranganathan Vlodek Siemionow Declan Walsh Guang H. Yue |
| author_sort | Didier Allexandre |
| collection | DOAJ |
| description | The neurophysiological mechanism of cancer-related fatigue (CRF) remains poorly understood. EEG was examined during a sustained submaximal contraction (SC) task to further understand our prior research findings of greater central contribution to early fatigue during SC in CRF. Advanced cancer patients and matched healthy controls performed an elbow flexor SC until task failure while undergoing neuromuscular testing and EEG recording. EEG power changes over left and right sensorimotor cortices were analyzed and correlated with brief fatigue inventory (BFI) score and evoked muscle force, a measure of central fatigue. Brain electrical activity changes during the SC differed in CRF from healthy subjects mainly in the theta (4-8 Hz) and beta (12-30 Hz) bands in the contralateral (to the fatigued limb) hemisphere; changes were correlated with the evoked force. Also, the gamma band (30-50 Hz) power decrease during the SC did not return to baseline after 2 min of rest in CRF, an effect correlated with BFI score. In conclusion, altered brain electrical activity during a fatigue task in patients is associated with central fatigue during SC or fatigue symptoms, suggesting its potential contribution to CRF during motor performance. This information should guide the development and use of rehabilitative interventions that target the central nervous system to maximize function recovery. |
| format | Article |
| id | doaj-art-66e5adf1408a469983b37befb6438f37 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-66e5adf1408a469983b37befb6438f372025-02-03T00:58:52ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88129848812984EEG Correlates of Central Origin of Cancer-Related FatigueDidier Allexandre0Dilara Seyidova-Khoshknabi1Mellar P. Davis2Vinoth K. Ranganathan3Vlodek Siemionow4Declan Walsh5Guang H. Yue6Center for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, USAThe Harry R. Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USAThe Harry R. Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USADepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USADepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USAThe Harry R. Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic, Cleveland, OH, USACenter for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, USAThe neurophysiological mechanism of cancer-related fatigue (CRF) remains poorly understood. EEG was examined during a sustained submaximal contraction (SC) task to further understand our prior research findings of greater central contribution to early fatigue during SC in CRF. Advanced cancer patients and matched healthy controls performed an elbow flexor SC until task failure while undergoing neuromuscular testing and EEG recording. EEG power changes over left and right sensorimotor cortices were analyzed and correlated with brief fatigue inventory (BFI) score and evoked muscle force, a measure of central fatigue. Brain electrical activity changes during the SC differed in CRF from healthy subjects mainly in the theta (4-8 Hz) and beta (12-30 Hz) bands in the contralateral (to the fatigued limb) hemisphere; changes were correlated with the evoked force. Also, the gamma band (30-50 Hz) power decrease during the SC did not return to baseline after 2 min of rest in CRF, an effect correlated with BFI score. In conclusion, altered brain electrical activity during a fatigue task in patients is associated with central fatigue during SC or fatigue symptoms, suggesting its potential contribution to CRF during motor performance. This information should guide the development and use of rehabilitative interventions that target the central nervous system to maximize function recovery.http://dx.doi.org/10.1155/2020/8812984 |
| spellingShingle | Didier Allexandre Dilara Seyidova-Khoshknabi Mellar P. Davis Vinoth K. Ranganathan Vlodek Siemionow Declan Walsh Guang H. Yue EEG Correlates of Central Origin of Cancer-Related Fatigue Neural Plasticity |
| title | EEG Correlates of Central Origin of Cancer-Related Fatigue |
| title_full | EEG Correlates of Central Origin of Cancer-Related Fatigue |
| title_fullStr | EEG Correlates of Central Origin of Cancer-Related Fatigue |
| title_full_unstemmed | EEG Correlates of Central Origin of Cancer-Related Fatigue |
| title_short | EEG Correlates of Central Origin of Cancer-Related Fatigue |
| title_sort | eeg correlates of central origin of cancer related fatigue |
| url | http://dx.doi.org/10.1155/2020/8812984 |
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