NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome

Abstract Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations and accelerated lung function decline. The relationshi...

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Main Authors: Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Tara Kenny, Christopher Morehouse, Carolina Caceres, Paul Warrener, Ventzislava A. Hristova, Susan Wilson, Harini Shandilya, Arnita Barnes, Alexey Ruzin, Junmin Wang, Lisa Oberg, Bastian Angermann, Christopher McCrae, Adam Platt, Daniel Muthas, Sonja Hess, Christine Tkaczyk, Bret R. Sellman, Kristoffer Ostridge, Maria G. Belvisi, Tom M. A. Wilkinson, Karl J. Staples, Antonio DiGiandomenico, on behalf of the MICA II Study Group
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
COPD
Non-typeable Haemophilus influenzae
Microbiome
Exacerbations
Online Access:https://doi.org/10.1186/s12931-025-03113-z
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