GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES
The research concerns the task of identification of contrasted single nucleotide polymorphisms (SNPs) obtained in genome-wide pooled allelotyping of 16 human cohorts, comprising healthy and ill persons, by the nested case–control approach. The genotyping platform was the Illumina Omni1S chip with 1....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/314 |
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| author | V. N. Babenko V. N. Maximov E. V. Kulakova E. S. Safronova M. I. Voevoda E. I. Rogaev |
| author_facet | V. N. Babenko V. N. Maximov E. V. Kulakova E. S. Safronova M. I. Voevoda E. I. Rogaev |
| author_sort | V. N. Babenko |
| collection | DOAJ |
| description | The research concerns the task of identification of contrasted single nucleotide polymorphisms (SNPs) obtained in genome-wide pooled allelotyping of 16 human cohorts, comprising healthy and ill persons, by the nested case–control approach. The genotyping platform was the Illumina Omni1S chip with 1.2 million markers. The mean pooled sample size was about 200 individuals. The candidate selection was based on statistical comparison of allele frequencies in a “case–control” study. Samples of ill patients show significant deviations from healthy persons in the numbers of significantly differing polymorphisms. The variance of allele frequencies among repeats in a single cohort was less than that in random choice of pairs from different cohorts. |
| format | Article |
| id | doaj-art-66dcb12dd4c9420d90b6ee7c6687d13f |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-66dcb12dd4c9420d90b6ee7c6687d13f2025-02-01T09:58:01ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01184/2847855297GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLESV. N. Babenko0V. N. Maximov1E. V. Kulakova2E. S. Safronova3M. I. Voevoda4E. I. Rogaev5Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Institute of Therapy SB RAMS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Novosibirsk National Research State University, Novosibirsk, Russia Institute of Therapy SB RAMS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Institute of Genetics RAS, Moscow, RussiaThe research concerns the task of identification of contrasted single nucleotide polymorphisms (SNPs) obtained in genome-wide pooled allelotyping of 16 human cohorts, comprising healthy and ill persons, by the nested case–control approach. The genotyping platform was the Illumina Omni1S chip with 1.2 million markers. The mean pooled sample size was about 200 individuals. The candidate selection was based on statistical comparison of allele frequencies in a “case–control” study. Samples of ill patients show significant deviations from healthy persons in the numbers of significantly differing polymorphisms. The variance of allele frequencies among repeats in a single cohort was less than that in random choice of pairs from different cohorts.https://vavilov.elpub.ru/jour/article/view/314genome-wide genotypingpooled sampleallele frequencysnp |
| spellingShingle | V. N. Babenko V. N. Maximov E. V. Kulakova E. S. Safronova M. I. Voevoda E. I. Rogaev GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES Вавиловский журнал генетики и селекции genome-wide genotyping pooled sample allele frequency snp |
| title | GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES |
| title_full | GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES |
| title_fullStr | GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES |
| title_full_unstemmed | GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES |
| title_short | GENOME-WIDE SNP ALLELOTYPING OF HUMAN COHORTS BY POOLED DNA SAMPLES |
| title_sort | genome wide snp allelotyping of human cohorts by pooled dna samples |
| topic | genome-wide genotyping pooled sample allele frequency snp |
| url | https://vavilov.elpub.ru/jour/article/view/314 |
| work_keys_str_mv | AT vnbabenko genomewidesnpallelotypingofhumancohortsbypooleddnasamples AT vnmaximov genomewidesnpallelotypingofhumancohortsbypooleddnasamples AT evkulakova genomewidesnpallelotypingofhumancohortsbypooleddnasamples AT essafronova genomewidesnpallelotypingofhumancohortsbypooleddnasamples AT mivoevoda genomewidesnpallelotypingofhumancohortsbypooleddnasamples AT eirogaev genomewidesnpallelotypingofhumancohortsbypooleddnasamples |