Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models

Identification and evaluation of a pinocembrin analog as a TRPV1 inhibitor with analgesic properties in murine pain models

IntroductionPain is a complex phenomenon involving physiological and psychological responses to noxious stimuli. Long-term opioid or NSAID use leads to reduced efficacy and tolerance. Initially a thermosensitive receptor, TRPV1 is increasingly recognized as a target for analgesic intervention.Method...

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Bibliographic Details
Main Authors: Hanbin Chen, Guanghong Li, Lin Deng, Nan Xu, Simon Ming-Yuen Lee, Xiaowei Nie, Jin-Song Bian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
virtual screening
molecular dynamics simulation
PINO analogue
analgesic
antiinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1585181/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1585181/full

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