Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells

Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells

Background: Light chain research is hampered by lack of mammalian cell lines producing human light chains (FLC). Therefore, we used heterohybridoma (HH) technology to produce clones making FLC thereby providing tools to study light chain behavior. Methods: Marrow CD138+ cells from patients with mult...

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Bibliographic Details
Main Authors: P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biochemistry and Biophysics Reports
Subjects:
Immunoglobulin light chains
Heterohybridomas
CD138
Plasma cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580825001049
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