Patients With Immunoglobulin A Nephropathy Show Abnormal Frequencies of B Cell Subsets, Unconventional T Cells, and High Levels of Galactose-Deficient IgA1–Coated Gut Bacteria

Patients With Immunoglobulin A Nephropathy Show Abnormal Frequencies of B Cell Subsets, Unconventional T Cells, and High Levels of Galactose-Deficient IgA1–Coated Gut Bacteria

Introduction: Mucosal inflammation is involved in the pathophysiology of immunoglobulin-A nephropathy (IgAN); however, peripheral immune phenotype analyses of patients with IgAN often do not include unconventional T cells, the major subset in mucosal immunity. Methods: We measured serum total IgA, g...

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Main Authors: Micaela Gentile, Nina Goerlich, I-Ju Lo, N. Eric Olson, Mark McConnell, Johannes Pospiech, Tobias Bohnenpoll, Philipp Skroblin, Olivier Radresa, Uwe Andag, Kirk N. Campbell, Kristin Meliambro, Luis Sanchez-Russo, Alberto Verlato, Enrico Fiaccadori, Seunghee Kim-Schulze, Maria Lanau, M. Loreto Fernandez-Lorente, Miguel Fribourg, Joaquin Manrique, Paolo Cravedi
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Kidney International Reports
Subjects:
B cell
IgA nephropathy
immune phenotype
innate immunity
T cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924020187
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