Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway

Dual targeting of tumoral cells and immune microenvironment by blocking the IL-33/IL1RL1 pathway

Abstract Leukemia stem cells (LSCs) are a small yet powerful subset of leukemic cells that possess the ability to self-renew and have a long-term tumorigenic capacity, playing a crucial role in both leukemia development and therapy resistance. These LSCs are influenced by external and internal facto...

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Main Authors: Denggang Fu, Hua Jiang, Alan Long, Ella Harris, Hongfen Guo, Maegan L. Capitano, John Wrangle, Joshua R. Faust, Anilkumar Gopalakrishnapillai, Santhosh Kumar Pasupuleti, Baskar Ramdas, Reuben Kapur, Sonali P. Barwe, Nai-Kong V. Cheung, Sophie Paczesny
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61567-7
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https://doi.org/10.1038/s41467-025-61567-7

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