Large-scale prediction shows that the dominant structure of the HIV-1 domain closed by the U5-AUG duplex contains the alternative SDa hairpin, and the domain variant without SD is rare

Large-scale prediction shows that the dominant structure of the HIV-1 domain closed by the U5-AUG duplex contains the alternative SDa hairpin, and the domain variant without SD is rare

Using several models of the HIV-1 5′ leader, it was shown that the domain containing the structural elements that regulate the processes of dimerization and genome packaging, as well as the initiation of reverse transcription, is closed by the U5-AUG duplex. However, there is no consensus in the lit...

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Bibliographic Details
Main Authors: M.I. Zarudnaya, A.L. Potyahaylo, L.G. Gorb
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Virus Research
Subjects:
HIV-1 M group
Phylogenetic analysis
RNA secondary structure
U5-AUG duplex
PBS segment
DIS hairpin
Online Access:http://www.sciencedirect.com/science/article/pii/S0168170225000589
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