Gastrointestinal exposure to silica nanoparticles induced Alzheimer’s disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC

Gastrointestinal exposure to silica nanoparticles induced Alzheimer’s disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-κB and HDAC

Abstract Background Silica nanoparticles (SiO2 NPs) are widely used in the food and pharmaceutical industries and dramatically increase the health risks associated with gastrointestinal exposure. However, the neurotoxicological effects and mechanisms of exposure to SiO2 NPs and their relationship wi...

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Bibliographic Details
Main Authors: Lisha Du, Benjie Wang, Xinyi Wang, Longxing Wang, Renjun Wang, Yuanyuan Zhang, Zemei Hong, Xiaofei Han, Yadong Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Silica nanoparticles
Gut-brain axis
Gut microbiota
Neurotoxicity
Biosecurity
Online Access:https://doi.org/10.1186/s12951-025-03481-0
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https://doi.org/10.1186/s12951-025-03481-0

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