Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in Escherichia coli

Mechanistic divergence between SOS response activation and antibiotic-induced plasmid conjugation in Escherichia coli

ABSTRACT The SOS response is a critical DNA damage repair mechanism in bacteria, designed to counteract genotoxic stress and ensure survival. This system can be activated by different classes of antimicrobial agents, each inducing the SOS response through different mechanisms. Moreover, it has been...

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Bibliographic Details
Main Authors: Ruoxuan Zhao, Arkadiusz Nawrocki, Jakob Møller-Jensen, Gang Liu, John Elmerdahl Olsen, Line Elnif Thomsen
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
SOS response
conjugation
antibiotics
Escherichia coli
IncI1
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00090-25
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