Development and preclinical characterization of AMG 329: a human antibody neutralizing FLT3 ligand

Development and preclinical characterization of AMG 329: a human antibody neutralizing FLT3 ligand

The feline McDonough sarcoma-like tyrosine kinase 3 (FLT3)/FLT3 ligand (FLT3L) signaling pathway regulates the development and activity of dendritic cells (DCs) and other myeloid cells, including monocytes. FLT3L, DCs, and monocytes have been implicated in several autoimmune diseases. Here, we descr...

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Bibliographic Details
Main Authors: Annie Lau-Kilby, Michele Gunsior, Agata Bartczak, Susan Chyou, James Hester, Dorothy Sims, Xiaodong Xiao, Peter Pavlik, Yan Chen, Kerry A. Casey, Kamelia Zerrouki, Qian Wang, M. Jack Borrok, Anna M. Hansen, William A. Rees
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
AMG 329
dendritic cells
FLT3
FLT3 ligand
plasmacytoid dendritic cells
monocytes
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2527677
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2527677

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