Dynamic endothelial cell rearrangements drive developmental vessel regression.

Dynamic endothelial cell rearrangements drive developmental vessel regression.

Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomos...

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Main Authors: Claudio A Franco, Martin L Jones, Miguel O Bernabeu, Ilse Geudens, Thomas Mathivet, Andre Rosa, Felicia M Lopes, Aida P Lima, Anan Ragab, Russell T Collins, Li-Kun Phng, Peter V Coveney, Holger Gerhardt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002125
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https://doi.org/10.1371/journal.pbio.1002125

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