C/EBPβ increases tumor aggressiveness by enhancing KIFC1 expression in androgen receptor negative triple negative breast cancer

C/EBPβ increases tumor aggressiveness by enhancing KIFC1 expression in androgen receptor negative triple negative breast cancer

Abstract Quadruple-negative breast cancers (also known as AR-triple negative (TN) BC) lack the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and androgen receptor (AR). AR-TNBC exhibits aggressive characteristics and a poor prognos...

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Main Authors: Shriya Joshi, Chakravarthy Garlapati, Thi Nguyen, Shaligram Sharma, Darshan Shimoga Chandrashekar, Shristi Bhattarai, Sooryanarayana Varambally, Uma Krishnamurti, Xiaoxian Li, Ritu Aneja
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
AR-TNBC
Proliferation
EMT
AR
C/EBPβ
KIFC1
Online Access:https://doi.org/10.1186/s12964-025-02243-7
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https://doi.org/10.1186/s12964-025-02243-7

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