PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands

PRMT5 inhibition has a potent anti-tumor activity against adenoid cystic carcinoma of salivary glands

Abstract Background Adenoid cystic carcinoma (ACC) is a rare glandular malignancy, commonly originating in salivary glands of the head and neck. Given its protracted growth, ACC is usually diagnosed in advanced stage. Treatment of ACC is limited to surgery and/or adjuvant radiotherapy, which often f...

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Main Authors: Vasudha Mishra, Alka Singh, Michael Korzinkin, Xiangying Cheng, Claudia Wing, Viktoria Sarkisova, Ashwin L. Koppayi, Alexandra Pogorelskaya, Oksana Glushchenko, Manu Sundaresan, Venkat Thodima, Jack Carter, Koichi Ito, Peggy Scherle, Anna Trzcinska, Ivan Ozerov, Everett E. Vokes, Grayson Cole, Frank W. Pun, Le Shen, Yuxuan Miao, Alexander T. Pearson, Mark W. Lingen, Bruce Ruggeri, Ari J. Rosenberg, Alex Zhavoronkov, Nishant Agrawal, Evgeny Izumchenko
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Adenoid cystic carcinoma (ACC)
Protein arginine methyl transferase 5 (PRMT5)
Organoid models
Patient derived xenografts (PDXs)
PandaOmics
Whole exome sequencing
Online Access:https://doi.org/10.1186/s13046-024-03270-x
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https://doi.org/10.1186/s13046-024-03270-x

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