Patient-specific computational simulation of coronary artery bypass grafting.
<h4>Introduction</h4>Coronary artery bypass graft surgery (CABG) is an intervention in patients with extensive obstructive coronary artery disease diagnosed with invasive coronary angiography. Here we present and test a novel application of non-invasive computational assessment of corona...
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| Format: | Article |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0281423&type=printable |
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| author | Wei Wu Anastasios Nikolaos Panagopoulos Charu Hasini Vasa Mohammadali Sharzehee Shijia Zhao Saurabhi Samant Usama M Oguz Behram Khan Abdallah Naser Khaled M Harmouch Ghassan S Kassab Aleem Siddique Yiannis S Chatzizisis |
| author_facet | Wei Wu Anastasios Nikolaos Panagopoulos Charu Hasini Vasa Mohammadali Sharzehee Shijia Zhao Saurabhi Samant Usama M Oguz Behram Khan Abdallah Naser Khaled M Harmouch Ghassan S Kassab Aleem Siddique Yiannis S Chatzizisis |
| author_sort | Wei Wu |
| collection | DOAJ |
| description | <h4>Introduction</h4>Coronary artery bypass graft surgery (CABG) is an intervention in patients with extensive obstructive coronary artery disease diagnosed with invasive coronary angiography. Here we present and test a novel application of non-invasive computational assessment of coronary hemodynamics before and after bypass grafting.<h4>Methods and results</h4>We tested the computational CABG platform in n = 2 post-CABG patients. The computationally calculated fractional flow reserve showed high agreement with the angiography-based fractional flow reserve. Furthermore, we performed multiscale computational fluid dynamics simulations of pre- and post-CABG under simulated resting and hyperemic conditions in n = 2 patient-specific anatomies 3D reconstructed from coronary computed tomography angiography. We computationally created different degrees of stenosis in the left anterior descending artery, and we showed that increasing severity of native artery stenosis resulted in augmented flow through the graft and improvement of resting and hyperemic flow in the distal part of the grafted native artery.<h4>Conclusions</h4>We presented a comprehensive patient-specific computational platform that can simulate the hemodynamic conditions before and after CABG and faithfully reproduce the hemodynamic effects of bypass grafting on the native coronary artery flow. Further clinical studies are warranted to validate this preliminary data. |
| format | Article |
| id | doaj-art-661e7b5e437c4046a22d13e05ae8c71d |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-661e7b5e437c4046a22d13e05ae8c71d2025-02-05T05:32:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183e028142310.1371/journal.pone.0281423Patient-specific computational simulation of coronary artery bypass grafting.Wei WuAnastasios Nikolaos PanagopoulosCharu Hasini VasaMohammadali SharzeheeShijia ZhaoSaurabhi SamantUsama M OguzBehram KhanAbdallah NaserKhaled M HarmouchGhassan S KassabAleem SiddiqueYiannis S Chatzizisis<h4>Introduction</h4>Coronary artery bypass graft surgery (CABG) is an intervention in patients with extensive obstructive coronary artery disease diagnosed with invasive coronary angiography. Here we present and test a novel application of non-invasive computational assessment of coronary hemodynamics before and after bypass grafting.<h4>Methods and results</h4>We tested the computational CABG platform in n = 2 post-CABG patients. The computationally calculated fractional flow reserve showed high agreement with the angiography-based fractional flow reserve. Furthermore, we performed multiscale computational fluid dynamics simulations of pre- and post-CABG under simulated resting and hyperemic conditions in n = 2 patient-specific anatomies 3D reconstructed from coronary computed tomography angiography. We computationally created different degrees of stenosis in the left anterior descending artery, and we showed that increasing severity of native artery stenosis resulted in augmented flow through the graft and improvement of resting and hyperemic flow in the distal part of the grafted native artery.<h4>Conclusions</h4>We presented a comprehensive patient-specific computational platform that can simulate the hemodynamic conditions before and after CABG and faithfully reproduce the hemodynamic effects of bypass grafting on the native coronary artery flow. Further clinical studies are warranted to validate this preliminary data.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0281423&type=printable |
| spellingShingle | Wei Wu Anastasios Nikolaos Panagopoulos Charu Hasini Vasa Mohammadali Sharzehee Shijia Zhao Saurabhi Samant Usama M Oguz Behram Khan Abdallah Naser Khaled M Harmouch Ghassan S Kassab Aleem Siddique Yiannis S Chatzizisis Patient-specific computational simulation of coronary artery bypass grafting. PLoS ONE |
| title | Patient-specific computational simulation of coronary artery bypass grafting. |
| title_full | Patient-specific computational simulation of coronary artery bypass grafting. |
| title_fullStr | Patient-specific computational simulation of coronary artery bypass grafting. |
| title_full_unstemmed | Patient-specific computational simulation of coronary artery bypass grafting. |
| title_short | Patient-specific computational simulation of coronary artery bypass grafting. |
| title_sort | patient specific computational simulation of coronary artery bypass grafting |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0281423&type=printable |
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