Impeding Nucleotide‐Binding Oligomerization Domain‐Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity‐Associated Cardiomyopathy

Impeding Nucleotide‐Binding Oligomerization Domain‐Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity‐Associated Cardiomyopathy

Background Inflammation and metabolic disturbances are key culprits in the pathogenesis of obesity‐associated cardiomyopathy. The NLRP3 (nucleotide‐binding oligomerization domain‐like receptor 3) inflammasome mediates the release of the proinflammatory cytokines IL‐1β (interleukin‐1β) and IL‐18 by a...

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Main Authors: Shi‐qiang Liu, Sai‐yang Xie, Tong Zhang, Heng Zhang, Meng‐Ya Chen, Yun Xing, Nan Zhao, Lanlan Li, Si Chen, Sha‐sha Wang, Xiao‐feng Zeng, Wei Deng, Qi‐Zhu Tang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
heart failure
MCC950
mitochondrial reactive oxygen species
MitoTEMPO
nuclear factor kappa B
TXNIP
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035234
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https://www.ahajournals.org/doi/10.1161/JAHA.124.035234

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