Analysis of Ferric Protoporphyrin IX Effects on Human Platelets: Hematin Is a More Potent Agonist than Hemin

Analysis of Ferric Protoporphyrin IX Effects on Human Platelets: Hematin Is a More Potent Agonist than Hemin

Hemolysis during severe diseases (malaria, hemorrhagic stroke, sickle cell disease, etc.) and blood transfusion induces the release of free hemoglobin, which degrades to highly reactive and toxic compounds—hemin and hematin. Oxidized heme derivatives induce platelet activation, aggregation, and degr...

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Bibliographic Details
Main Authors: Diana M. Mikhailova, Julia Sudnitsyna, Polina Kovgan, Lidia Naida, Alexandra Kharazova, Igor Mindukshev, Stepan Gambaryan
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
platelets
hematin
hemin
aggregation
shape change
albumin
Online Access:https://www.mdpi.com/2073-4409/14/4/255
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