Pembrolizumab with external radiation therapy effectively controlled TMB-high unresectable recurrent parathyroid cancer: a case report with review of literature

Pembrolizumab with external radiation therapy effectively controlled TMB-high unresectable recurrent parathyroid cancer: a case report with review of literature

Parathyroid cancer (PC) is extremely resistant to chemotherapy and radiotherapy (RT), but hormonally functional by producing excessive parathyroid hormone (PTH), causing remarkable hypercalcemia even in biochemical disease recurrence. Accordingly, management of hypercalcemia by calcimimetics and bis...

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Bibliographic Details
Main Authors: Hiroshi Katoh, Tomoya Mitsuma, Riku Okamoto, Kanako Naito, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai
Format: Article
Language:English
Published: The Japan Endocrine Society 2024-11-01
Series:Endocrine Journal
Subjects:
pembrolizumab
radiation therapy
parathyroid cancer
unresectable
tumor mutational burden (tmb)
Online Access:https://www.jstage.jst.go.jp/article/endocrj/71/11/71_EJ24-0126/_html/-char/en
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https://www.jstage.jst.go.jp/article/endocrj/71/11/71_EJ24-0126/_html/-char/en

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