The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription

The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcription

Abstract Addiction to oncogene-rewired transcriptional networks is a therapeutic vulnerability in cancer cells, underscoring a need to better understand mechanisms that relay oncogene signals to the transcriptional machinery. Here, using human and mouse T cell acute lymphoblastic leukemia (T-ALL) mo...

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Main Authors: Katharine Umphred-Wilson, Shashikala Ratnayake, Qianzi Tang, Rui Wang, Sneha Ghosh Chaudhary, Devaiah N. Ballachanda, Josephine Trichka, Jan Wisniewski, Lan Zhou, Qingrong Chen, Daoud Meerzaman, Dinah S. Singer, Stanley Adoro
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59504-9
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https://doi.org/10.1038/s41467-025-59504-9

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