IL-17A regulates airway remodelling in COPD through the PI3K/AKT/mTOR pathway

IL-17A regulates airway remodelling in COPD through the PI3K/AKT/mTOR pathway

Abstract The airway and lung tissue inflammation and structural changes caused by COPD lead to persistent and irreversible airflow limitation in patients. Several studies have associated IL-17A with COPD airway inflammation and collagen deposition, while autophagy is essential for maintaining normal...

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Bibliographic Details
Main Authors: Ting Ding, Shunshun Zhao, Yanhui Gu, Guiqiang He, Yanzhu Lang, Ximin Rao, Jie Chen, Yao Ou-Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
IL-17A
COPD airway remodelling
Mouse bronchial fibroblasts
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-00458-9
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https://doi.org/10.1038/s41598-025-00458-9

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