The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity
Nanomaterials have been found increasing applications in the food sector. Nanostructured antimicrobials can be incorporated either to food matrix of food packaging or to provide extended safety and quality. However, the interactions and effects of nanomaterials with biological systems are still poor...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2020-03-01
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| Series: | Food Science and Human Wellness |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453019301223 |
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| author | Adriano Brandelli |
| author_facet | Adriano Brandelli |
| author_sort | Adriano Brandelli |
| collection | DOAJ |
| description | Nanomaterials have been found increasing applications in the food sector. Nanostructured antimicrobials can be incorporated either to food matrix of food packaging or to provide extended safety and quality. However, the interactions and effects of nanomaterials with biological systems are still poorly understood. Nanoparticles can enter the organism by oral, dermal and inhalation routes and distributed to different tissues by the circulatory system. Increasing evidence indicate that targeting to specific tissues, cellular uptake and intracellular fate of nanoparticles are strongly influenced by size, shape and surface properties. The specific characteristics of nanomaterials are also determinant for their toxicity in higher organisms. The dose, exposure time and administration route are important aspects influencing toxicity of nanoparticles as well. Both in vitro and in vivo evaluation studies on different types of nanostructures have providing information to support a better understanding about the interactions of nanoscale materials with biological systems. Keywords: Active packaging, Antimicrobial, Food safety, Nanobiotechnology, Nanoparticle toxicity |
| format | Article |
| id | doaj-art-6520f6c9318146f9a56c9b5829cbabe5 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-6520f6c9318146f9a56c9b5829cbabe52025-02-03T05:21:19ZengTsinghua University PressFood Science and Human Wellness2213-45302020-03-0191820The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicityAdriano Brandelli0Centro de Nanociência e Nanotecnologia, Universidade Federal do Rio Grande do Sul, ICTA-UFRGS, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, BrazilNanomaterials have been found increasing applications in the food sector. Nanostructured antimicrobials can be incorporated either to food matrix of food packaging or to provide extended safety and quality. However, the interactions and effects of nanomaterials with biological systems are still poorly understood. Nanoparticles can enter the organism by oral, dermal and inhalation routes and distributed to different tissues by the circulatory system. Increasing evidence indicate that targeting to specific tissues, cellular uptake and intracellular fate of nanoparticles are strongly influenced by size, shape and surface properties. The specific characteristics of nanomaterials are also determinant for their toxicity in higher organisms. The dose, exposure time and administration route are important aspects influencing toxicity of nanoparticles as well. Both in vitro and in vivo evaluation studies on different types of nanostructures have providing information to support a better understanding about the interactions of nanoscale materials with biological systems. Keywords: Active packaging, Antimicrobial, Food safety, Nanobiotechnology, Nanoparticle toxicityhttp://www.sciencedirect.com/science/article/pii/S2213453019301223 |
| spellingShingle | Adriano Brandelli The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity Food Science and Human Wellness |
| title | The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity |
| title_full | The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity |
| title_fullStr | The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity |
| title_full_unstemmed | The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity |
| title_short | The interaction of nanostructured antimicrobials with biological systems: Cellular uptake, trafficking and potential toxicity |
| title_sort | interaction of nanostructured antimicrobials with biological systems cellular uptake trafficking and potential toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2213453019301223 |
| work_keys_str_mv | AT adrianobrandelli theinteractionofnanostructuredantimicrobialswithbiologicalsystemscellularuptaketraffickingandpotentialtoxicity AT adrianobrandelli interactionofnanostructuredantimicrobialswithbiologicalsystemscellularuptaketraffickingandpotentialtoxicity |