A microfluidic platform for anterior-posterior human endoderm patterning via countervailing morphogen gradients in vitro

A microfluidic platform for anterior-posterior human endoderm patterning via countervailing morphogen gradients in vitro

Summary: Understanding how morphogen gradients spatially pattern tissues is a fundamental question in developmental biology but can be difficult to directly address using conventional approaches. Here, we expose hPSC-derived endoderm cells to countervailing gradients of anteriorizing and posterioriz...

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Main Authors: Leeya Engel, Kevin J. Liu, Kiara W. Cui, Eva L. de la Serna, Vipul T. Vachharajani, Carolyn E. Dundes, Sherry Li Zheng, Manali Begur, Kyle M. Loh, Lay Teng Ang, Alexander R. Dunn
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:iScience
Subjects:
Cell biology
Developmental biology
Fluidics
Methodology in biological sciences
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225000033
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http://www.sciencedirect.com/science/article/pii/S2589004225000033

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