Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion
The main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome (n=9) and in children with (n=80) and without (n=40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5853167 |
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| author | Justyna Paprocka Marek Kijonka Piotr Wojcieszek Marcin Pęcka Ewa Emich-Widera Maria Sokół |
| author_facet | Justyna Paprocka Marek Kijonka Piotr Wojcieszek Marcin Pęcka Ewa Emich-Widera Maria Sokół |
| author_sort | Justyna Paprocka |
| collection | DOAJ |
| description | The main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome (n=9) and in children with (n=80) and without (n=40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian secretion. The characteristics describing the diurnal hormone secretion such as minimum melatonin concentration, release amplitude, phase shift of melatonin release, and sleep duration as well as the dim light melatonin onset (DLMO) of melatonin secretion and the γ shape parameter allow analyzing the fit and deducing about how much the measured melatonin profile differs from a physiological bell-shaped secretion. The estimated sleep duration and phase shift of melatonin release as well as the DMLO offsets at 25% and 50% relative thresholds are the key characteristic of Angelman syndrome children. As revealed from the γ shape parameter, the melatonin secretion profiles are disturbed in majority of the AG subjects revealing rather a triangular course instead of the bell-like one. |
| format | Article |
| id | doaj-art-65110d2472ad41cf8e8dc6f6d46f1ae8 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-65110d2472ad41cf8e8dc6f6d46f1ae82025-02-03T01:12:49ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/58531675853167Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal SecretionJustyna Paprocka0Marek Kijonka1Piotr Wojcieszek2Marcin Pęcka3Ewa Emich-Widera4Maria Sokół5Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, PolandBrachytherapy Department, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, PolandFaculty of Automatic Control, Electronics and Computer Science Biomedical Engineering, Silesian University of Technology, Gliwice, PolandDepartment of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, PolandDepartment of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch, Gliwice, PolandThe main aim of the study was to compare the melatonin rhythms in subjects with Angelman syndrome (n=9) and in children with (n=80) and without (n=40) epilepsy (nonepileptic patients diagnosed with peripheral nerve palsies, myopathy, and back pain) using our mathematical model of melatonin circadian secretion. The characteristics describing the diurnal hormone secretion such as minimum melatonin concentration, release amplitude, phase shift of melatonin release, and sleep duration as well as the dim light melatonin onset (DLMO) of melatonin secretion and the γ shape parameter allow analyzing the fit and deducing about how much the measured melatonin profile differs from a physiological bell-shaped secretion. The estimated sleep duration and phase shift of melatonin release as well as the DMLO offsets at 25% and 50% relative thresholds are the key characteristic of Angelman syndrome children. As revealed from the γ shape parameter, the melatonin secretion profiles are disturbed in majority of the AG subjects revealing rather a triangular course instead of the bell-like one.http://dx.doi.org/10.1155/2017/5853167 |
| spellingShingle | Justyna Paprocka Marek Kijonka Piotr Wojcieszek Marcin Pęcka Ewa Emich-Widera Maria Sokół Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion International Journal of Endocrinology |
| title | Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion |
| title_full | Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion |
| title_fullStr | Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion |
| title_full_unstemmed | Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion |
| title_short | Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion |
| title_sort | melatonin and angelman syndrome implications and mathematical model of diurnal secretion |
| url | http://dx.doi.org/10.1155/2017/5853167 |
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