Proteasomal activation ameliorates neuronal phenotypes linked to FBXO11-deficiency

Proteasomal activation ameliorates neuronal phenotypes linked to FBXO11-deficiency

Summary: Haploinsufficiency of FBXO11, encoding a ubiquitin ligase complex subunit, is associated with a variable neurodevelopmental disorder. So far, the underlying nervous system-related pathomechanisms are poorly understood, and specific therapies are lacking. Using a combined approach, we establ...

Full description

Saved in:
Bibliographic Details
Main Authors: Anne Gregor, Laila Distel, Arif B. Ekici, Philipp Kirchner, Steffen Uebe, Mandy Krumbiegel, Soeren Turan, Beate Winner, Christiane Zweier
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:HGG Advances
Subjects:
neurodevelopmental disorder
Drosophila melanogaster
disease modeling
targeted therapy
hIPSC-based neuronal cells
drug repurposing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247725000284
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2666247725000284

Similar Items