stClinic dissects clinically relevant niches by integrating spatial multi-slice multi-omics data in dynamic graphs

Abstract Spatial multi-slice multi-omics (SMSMO) integration has transformed our understanding of cellular niches, particularly in tumors. However, challenges like data scale and diversity, disease heterogeneity, and limited sample population size, impede the derivation of clinical insights. Here, w...

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Bibliographic Details
Main Authors: Chunman Zuo, Junjie Xia, Yupeng Xu, Ying Xu, Pingting Gao, Jing Zhang, Yan Wang, Luonan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60575-x
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