Dissecting the Immunological Microenvironment of Glioma Based on IDH Status: Implications for Immunotherapy

Dissecting the Immunological Microenvironment of Glioma Based on IDH Status: Implications for Immunotherapy

Gliomas, particularly IDH-wildtype ones, are associated with poor prognosis, yet their immunological landscape remains uncertain. We analyzed RNA sequencing data from 55 glioma patients, estimating immune infiltration with CIBERSORTx and immune cell states via Ecotyper. IDH-wildtype gliomas showed s...

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Main Authors: Miyu Kikuchi, Hirokazu Takami, Yukari Kobayashi, Koji Nagaoka, Yosuke Kitagawa, Masashi Nomura, Shunsaku Takayanagi, Shota Tanaka, Nobuhito Saito, Kazuhiro Kakimi
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
glioma
IDH status
tumor microenvironment
immunotherapy
tumor-infiltrating lymphocytes
immune checkpoint inhibitors
Online Access:https://www.mdpi.com/2073-4409/14/13/1035
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